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    The description :cetpi forum -- -- cetpi forum is intended for use by healthcare professionals and not patients. you should always contact your doctor or medical professional for further help and advice. skip to conte...

    This report updates in 21-Dec-2018

Created Date:2007-10-17

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cetpi forum -- -- cetpi forum is intended for use by healthcare professionals and not patients. you should always contact your doctor or medical professional for further help and advice. skip to content home summary resources slides societies guidelines links glossary ask the expert viewpoints cetpi essentials about cetpi forum about hdl forum register   -- contact « 01 cetpi essentials 02 guidelines 03 resources » pause frontpage slideshow (version 2.0.0) - copyright © 2006-2008 by joomlaworks dalcetrapib: 48 week trial dalcetrapib is a cholesteryl ester transfer protein (cetp) inhibitor in phase iii development. in this study in patients with or at high risk of coronary heart disease, treatment with dalcetrapib 900 mg/day for 24 to 48 weeks substantially increased hdl cholesterol levels (by about 30%). there was no evidence of clinically relevant changes in blood pressure or aldosterone or increase in adverse events with dalcetrapib. -- download full powerpoint presentation -- raising hdl cholesterol: therapeutic considerations low hdl cholesterol is recognized as a cardiovascular risk factor by guideline groups, especially among individuals with metabolic syndrome or type 2 diabetes mellitus. in these patients, low hdl cholesterol is typically associated with elevated triglycerides (often referred to as atherogenic dyslipidemia). read more... this slide series overviews the relevance of different therapeutic options - both currently available and investigational – for raising hdl cholesterol. at the recommended therapeutic dose of 2000 mg daily, extended-release (er) niacin raises hdl cholesterol by about 20-30%. reference 1. chapman mj et al. pharmacol ther 2010;126:314-345 the coronary drug project (cdp) is so far the only published outcomes study with niacin (nicotinic acid, immediate-release formulation) monotherapy. at 15 years (nearly 9 years after termination of the trial) total mortality in the niacin group was 11% lower than in the placebo group (p=0.0004). chd mortality was also significantly decreased in the niacin group (12% reduction, p<0.05). however, mortality at 15 years was not an original end point of the cdp, patients had not received niacin for approximately 9 years, and confounding variables such as concomitant medication use and medical or surgical treatments, were not controlled in this follow-up study. results from this follow-up study indicated that early treatment with niacin may provide a mortality benefit over subsequent years, even after discontinuation of niacin. reference canner pl et al. j am coll cardiol 1986;8:1245-55. . compell: comparative effects of combination therapy versus statin monotherapy. the compell study evaluated comparative effects on lipid levels of combination therapy with er niacin and low to moderate doses of a statin (atorvastatin or rosuvastatin), simvastatin plus ezetimibe, and rosuvastatin monotherapy. this was an open-label, multicentre, 12-week study in 292 patients (50% women) who qualified for lipid-modifying therapy based on a number of coronary risk factors. doses of statins and niacin were titrated up over the 12 weeks. at 12 weeks, all groups lowered ldl cholesterol by more than 50%, with no significant differences among treatment groups. statin/er niacin combination regimens increased hdl cholesterol and lowered triglycerides and lipoprotein(a) significantly more than the other regimens (p<.001 for analysis of variance across groups). in summary, low to moderate dose combination therapy with a statin and er niacin provided broad control of lipids and lipoproteins independently associated with coronary heart disease. reference mckenney jm et al. atherosclerosis. 2007;192:432-437. the seacoast trial evaluated the effects of combination therapy with a statin and two doses of er niacin in dyslipidemic patients. patients were initially enrolled in a run-in phase during which they discontinued all other lipid-modifying therapy and were treated with simvastatin (variable dose), in addition to a standard cholesterol-lowering diet. following this phase more than 600 patients were randomly assigned to either the low-dose (20 mg) or high-dose (40 mg) • simvastatin arm. patients in the low-dose group (seacoast i) were randomized to: • er niacin 1 g/simvastatin 20 mg; • er niacin 2 g/simvastatin 20 mg; or • simvastatin 20 mg. patients in the high-dose group (seacoast ii) were randomized to: • er niacin 2 g/simvastatin 40 mg; • er niacin 1 g/simvastatin 40 mg; or • simvastatin 80 mg. patients in the simvastatin monotherapy groups received a 50 mg dose of immediate-release niacin to maintain study blinding. reference ballantyne cm et al. am j cardiol 2008;101:1428-36. seacoast i was aimed at demonstrating the superiority of er niacin/simvastatin vs simvastatin monotherapy in patients already at ncep atp iii coronary heart disease risk-adjusted target ldl cholesterol levels. patients receiving niacin-statin combination treatment achieved 18% (1 g/20 mg) and 25% (2 g/20 mg) increases in hdl cholesterol vs 7% reduction with simvastatin 20 mg alone. combination treatment also significantly reduced ldl cholesterol, non-hdl cholesterol, lipoprotein(a) and triglycerides compared with simvastatin monotherapy. reference ballantyne cm et al. am j cardiol 2008;101:1428-36. in seacoast ii, combination therapy showed non-inferiority in reducing non-hdl cholesterol, with decreases of about 11% (1 g/40 mg) and 17% (2 g/40 mg) compared with a 10% reduction with simvastatin 80 mg alone. both combination treatment doses were associated with significant improvements in hdl cholesterol, triglycerides, lipoprotein(a) and apolipoprotein a-1. reference ballantyne cm et al. am j cardiol 2008;101:1428-36. flushing is the main tolerability issue with niacin therapy. the combination of niacin with laropiprant, an inhibitor of the prostaglandin d2 receptor, was developed in attempt to manage this. in this study, patients treated with er-niacin/laropiprant had significantly less flushing than those treated with er-niacin over the 16-week period. overall, more than twice as many patients reported no episodes of moderate, severe or extreme flushing with er-niacin/laropiprant than er-niacin (47% vs. 22%). additionally, treatment with er-niacin/laropiprant was associated with significantly less severe/extreme flushing (24.4% vs. 50.8%, p<0.001). reference maccubbin d et al. am j cardiol 2009;104:74-81. hats: hdl atherosclerosis treatment study hats evaluated the effect of combination treatment with simvastatin plus niacin in 160 patients with coronary heart disease and low hdl cholesterol levels and normal ldl cholesterol levels. combination therapy resulted in a 29% increase in plasma levels of hdl cholesterol (versus 6% with placebo) together with reductions of 38% (versus 3%) in triglycerides and 43% (versus 9%) in ldl cholesterol. after 3 years, there was significant angiographic regression of stenosis by 0.4% on average, compared with placebo (p<0.001); the addition of anti-oxidants had no influence on this effect. however, hats did not include a separate simvastatin treatment arm and therefore the incremental benefit of nicotinic acid over statin alone could not be discerned. reference brown bg et al. n engl j med 2001;345:1583-92. arbiter-2: arterial biology for the investigation of the treatment effects of reducing cholesterol study arbiter 2 included 167 patients with known coronary heart disease, moderately low hdl cholesterol (< 45 mg/dl [1.2 mmol/l]) and well-controlled ldl cholesterol (< 100 mg/dl [2.6 mmol/l]), who had been treated with a statin (93% with simvastatin) for an average of 4.8 years. patients were randomised to treatment with er niacin (500 mg for the first 30 days and 1000 mg daily thereafter) or placebo in addition to statin therapy for 12 months. the primary endpoint of the study was the change in carotid intima-media thickness (cimt) at 12 months, as measured by b-mode u

URL analysis for cetpiforum.org


https://www.cetpiforum.org/ask-the-expert/viewpoints.html
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https://www.cetpiforum.org/index9075.html?start=15
https://www.cetpiforum.org/component/content/article/47-slides/341-dal-plaque.html
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https://www.cetpiforum.org/raising-hdl-cholesterol-therapeutic-considerations.html
https://www.cetpiforum.org/hdl-cholesterol-and-cardiovascular-risk-an-overview-of-epidemiological-evidence.html
https://www.cetpiforum.org/professor-john-chapman.html
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Domain Name: CETPIFORUM.ORG
Registry Domain ID: D149429100-LROR
Registrar WHOIS Server: whois.meshdigital.com
Registrar URL: http://www.domainmonster.com
Updated Date: 2018-02-28T15:40:20Z
Creation Date: 2007-10-17T12:20:05Z
Registry Expiry Date: 2019-10-17T12:20:05Z
Registrar Registration Expiration Date:
Registrar: Mesh Digital Limited
Registrar IANA ID: 1390
Registrar Abuse Contact Email: [email protected]
Registrar Abuse Contact Phone: +44.1483304030
Reseller:
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Registry Registrant ID: C202151078-LROR
Registrant Name: Alison Langdon
Registrant Organization: SHERBORNE GIBBS LTD
Registrant Street: Minerva Mill Innovation Centre
Registrant Street: Station Road
Registrant City: Alcester
Registrant State/Province: Warks
Registrant Postal Code: B49 5ET
Registrant Country: GB
Registrant Phone: +44.1789766098
Registrant Phone Ext:
Registrant Fax:
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Registrant Email: [email protected]
Registry Admin ID: C202151079-LROR
Admin Name: Alison
Admin Organization: SHERBORNE GIBBS LTD
Admin Street: Minerva Mill Innovation Centre
Admin Street: Station Road
Admin City: Alcester
Admin State/Province: Warks
Admin Postal Code: B49 5ET
Admin Country: GB
Admin Phone: +44.1789766098
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Registry Tech ID: C202151080-LROR
Tech Name: Webfusion Limited
Tech Organization: Webfusion Limited
Tech Street: 5 Roundwood Avenue
Tech City: Stockley Park
Tech State/Province: Uxbridge
Tech Postal Code: UB11 1FF
Tech Country: GB
Tech Phone: +44.8712309525
Tech Phone Ext:
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Name Server: NS.123-REG.CO.UK
Name Server: NS2.123-REG.CO.UK
DNSSEC: unsigned
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SERVERS

  SERVER org.whois-servers.net

  ARGS cetpiforum.org

  PORT 43

  TYPE domain

DOMAIN

  NAME cetpiforum.org

  HANDLE D149429100-LROR

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STATUS
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NSERVER

  NS.123-REG.CO.UK 212.67.202.2

  NS2.123-REG.CO.UK 62.138.132.21

OWNER

  HANDLE C202151078-LROR

  NAME Alison Langdon

  ORGANIZATION SHERBORNE GIBBS LTD

ADDRESS

STREET
Minerva Mill Innovation Centre
Station Road

  CITY Alcester

  STATE Warks

  PCODE B49 5ET

  COUNTRY GB

  PHONE +44.1789766098

  EMAIL [email protected]

ADMIN

  HANDLE C202151079-LROR

  NAME Alison

  ORGANIZATION SHERBORNE GIBBS LTD

ADDRESS

STREET
Minerva Mill Innovation Centre
Station Road

  CITY Alcester

  STATE Warks

  PCODE B49 5ET

  COUNTRY GB

  PHONE +44.1789766098

  EMAIL [email protected]

TECH

  HANDLE C202151080-LROR

  NAME Webfusion Limited

  ORGANIZATION Webfusion Limited

ADDRESS

STREET
5 Roundwood Avenue

  CITY Stockley Park

  STATE Uxbridge

  PCODE UB11 1FF

  COUNTRY GB

  PHONE +44.8712309525

  EMAIL [email protected]

  REGISTERED yes

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